Sollelis, L. and Marti, M. (2018) A major step towards defining the elusive stumpy inducing factor in Trypanosoma brucei. Trends in Parasitology, 35(1), pp. 6-8. (doi: 10.1016/j.pt.2018.11.009) (PMID:30554967)
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Abstract
Trypanosoma brucei stumpy forms are the only stage that can transmit from human to tsetse fly. Stumpy formation is regulated by a quorum sensing mechanism that depends on parasite density and an unknown stumpy induction factor (SIF). Recently, an elegant study by Matthews and colleagues (Cell 176, 1-12) has identified several crucial components of this pathway, including the putative SIF and its receptor.
| Item Type: | Articles |
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| Keywords: | Trypanosoma brucei, differentiation, sleeping sickness, slender form, stumpy form, stumpy inducing factor. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Sollelis, Miss Lauriane and Marti, Professor Matthias |
| Authors: | Sollelis, L., and Marti, M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Trends in Parasitology |
| Publisher: | Elsevier |
| ISSN: | 1471-4922 |
| ISSN (Online): | 1471-5007 |
| Copyright Holders: | Copyright © 2018 Elsevier Ltd. |
| First Published: | First published in Trends in Parasitology 35(1):6-8 |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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