The diverse roles of the eIF4A family: you are the company you keep

Lu, W.-T., Wilczynska, A., Smith, E. and Bushell, M. (2014) The diverse roles of the eIF4A family: you are the company you keep. Biochemical Society Transactions, 42(1), pp. 166-172. (doi: 10.1042/BST20130161) (PMID:24450646)

Full text not currently available from Enlighten.


The eIF4A (eukaryotic initiation factor 4A) proteins belong to the extensive DEAD-box RNA helicase family, the members of which are involved in many aspects of RNA metabolism by virtue of their RNA-binding capacity and ATPase activity. Three eIF4A proteins have been characterized in vertebrates: eIF4A1 and eIF4A2 are cytoplasmic, whereas eIF4A3 is nuclear-localized. Although highly similar, they have been shown to possess rather diverse roles in the mRNA lifecycle. Their specific and diverse functions are often regulated and dictated by interacting partner proteins. The key differences between eIF4A family members are discussed in the present review.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Bushell, Professor Martin
Authors: Lu, W.-T., Wilczynska, A., Smith, E., and Bushell, M.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Biochemical Society Transactions
Publisher:Portland Press
ISSN (Online):1470-8752
Published Online:23 January 2014

University Staff: Request a correction | Enlighten Editors: Update this record