Leptin Predicts Diabetes but Not Cardiovascular Disease Results from a large prospective study in an elderly population

Welsh, P. et al. (2009) Leptin Predicts Diabetes but Not Cardiovascular Disease Results from a large prospective study in an elderly population. Diabetes Care, 32(2), pp. 308-310. (doi: 10.2337/dc08-1458)

Abstract

OBJECTIVE - To clarify the association of circulating levels of leptin With risk for cardiovascular disease (CVD) events and new-onset diabetes in men and women. RESEARCH DESIGN AND METHODS - We related baseline leptin levels to CVD events (n = 864) and incident diabetes (n = 289) in an elderly population (n = 5,672) over 3.2 years of follow-up. RESULTS - In treatment-, age-, and country-adjusted models, leptin was not associated with risk of CVD in men (hazard ratio 1.02 [95% CI 0.90-1.16] per unit log-leptin increase) or women 0.05 [0.91-1.20]) but was associated with risk of diabetes in men (2.75 [2.14-3.52]) and women (1.54 [1.22-1.94]). After adjusting for classic risk factors and BMI, C-reactive protein, and glucose, the diabetes association retained significance in men (1.85 [1.30-2.63]) but not in women (0.89 [0.64-1.26]). CONCLUSIONS - Leptin, similar to other markers of adiposity in general, is more Strongly related to risk of diabetes than CVD in the elderly.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Macfarlane, Professor Peter and Welsh, Professor Paul and Stott J, Professor David and Ford, Professor Ian and Shepherd, Prof James and Murray, Mrs Heather and Sattar, Professor Naveed
• Authors: Welsh, P., Murray, H., Buckley, B., De Craen, A., Ford, I., Jukema, J., Macfarlane, P., Packard, C., Stott, D., Westendorp, R., Shepherd, J., and Sattar, N.
• College/School: College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre; College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Diabetes Care
• Publisher: American Diabetes Association
• ISSN: 0149-5992
• Published Online: 10 November 2008