Maizels, R. , Smits, H. H. and McSorley, H. J. (2018) Modulation of host immunity by helminths: the expanding repertoire of parasite effector molecules. Immunity, 49(5), pp. 801-818. (doi: 10.1016/j.immuni.2018.10.016) (PMID:30462997) (PMCID:PMC6269126)
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Abstract
Helminths are extraordinarily successful parasites due to their ability to modulate the host immune response. They have evolved a spectrum of immunomodulatory molecules that are now beginning to be defined, heralding a molecular revolution in parasite immunology. These discoveries have the potential both to transform our understanding of parasite adaptation to the host and to develop possible therapies for immune-mediated disease. In this review we will summarize the current state of the art in parasite immunomodulation and discuss perspectives on future areas for research and discovery.
| Item Type: | Articles |
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| Additional Information: | R.M.M. is supported by the Wellcome Trust through an Investigator Award (106122), by the Kenneth Rainin Foundation (2016-3067), and by core funding to the Wellcome Centre for Molecular Parasitology (104111). H.H.S. is supported by a ZonMW-VIDI grant (91714352) from the Netherlands Organisation for Scientific Research and a Consortium Grant (5115015) from the Netherlands Lung Foundation. R.M.M., H.H.S., and H.J.M. are supported by a Consortium grant (12017001) from the Netherlands Lung Foundation Accelerate Programme. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Maizels, Professor Rick |
| Authors: | Maizels, R., Smits, H. H., and McSorley, H. J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Immunity |
| Publisher: | Elsevier |
| ISSN: | 1074-7613 |
| ISSN (Online): | 1097-4180 |
| Published Online: | 20 November 2018 |
| Copyright Holders: | Copyright © 2018 The Authors |
| First Published: | First published in Immunity 49:801-818 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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