The chemokine receptor CXCR2 contributes to murine adipocyte development

Dyer, D. P. , Nebot, J. B., Kelly, C. J., Medina-Ruiz, L., Schuette, F. and Graham, G. J. (2019) The chemokine receptor CXCR2 contributes to murine adipocyte development. Journal of Leukocyte Biology, 105(3), pp. 497-506. (doi: 10.1002/JLB.1A0618-216RR) (PMID:30517976) (PMCID:PMC6392114)

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Abstract

Chemokines are members of a large family of chemotactic cytokines that signal through their receptors to mediate leukocyte recruitment during inflammation and homeostasis. The chemokine receptor CXCR2 has largely been associated with neutrophil recruitment. However, there is emerging evidence of roles for chemokines and their receptors in processes other than leukocyte migration. We have previously demonstrated that CXCR2 knockout (KO) mice have thinner skin compared to wild‐type mice. Herein we demonstrate that this is due to a thinner subcutaneous adipose layer, as a result of fewer and smaller individual adipocytes. We observe a similar phenotype in other fat depots and present data that suggests this may be due to reduced expression of adipogenesis related genes associated with adipocyte specific CXCR2 signaling. Interestingly, this phenotype is evident in female, but not male, CXCR2 KO mice. These findings expand our understanding of nonleukocyte related chemokine receptor functions and help to explain some previously observed adipose‐related phenotypes in CXCR2 KO mice.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kelly, Dr Christopher and Dyer, Dr Douglas and Schuette, Dr Fabian and Medina-Ruiz, Dr Laura and Graham, Professor Gerard
Authors: Dyer, D. P., Nebot, J. B., Kelly, C. J., Medina-Ruiz, L., Schuette, F., and Graham, G. J.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Journal of Leukocyte Biology
Publisher:Wiley
ISSN:0741-5400
ISSN (Online):1938-3673
Published Online:05 December 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Journal of Leukocyte Biology 105(3): 497-506
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
600961Dissecting the chemokine basis for the orchestration of the in vivo inflammatory responseGerard GrahamWellcome Trust (WELLCOTR)099251/Z/12/ZIII -IMMUNOLOGY
681091The ACKR2-CCR2 axis in development and diseaseGerard GrahamMedical Research Council (MRC)MR/M019764/1III -IMMUNOLOGY