Mas-Moruno, C., Su, B. and Dalby, M. J. (2019) Multifunctional coatings and nanotopographies: towards cell instructive and antibacterial implants. Advanced Healthcare Materials, 8(1), 1801103. (doi: 10.1002/adhm.201801103) (PMID:30468010)
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Abstract
In biomaterials science, it is nowadays well accepted that improving the biointegration of dental and orthopedic implants with surrounding tissues is a major goal. However, implant surfaces that support osteointegration may also favor colonization of bacterial cells. Infection of biomaterials and subsequent biofilm formation can have devastating effects and reduce patient quality of life, representing an emerging concern in healthcare. Conversely, efforts toward inhibiting bacterial colonization may impair biomaterial–tissue integration. Therefore, to improve the long‐term success of medical implants, biomaterial surfaces should ideally discourage the attachment of bacteria without affecting eukaryotic cell functions. However, most current strategies seldom investigate a combined goal. This work reviews recent strategies of surface modification to simultaneously address implant biointegration while mitigating bacterial infections. To this end, two emerging solutions are considered, multifunctional chemical coatings and nanotopographical features.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Dalby, Professor Matthew |
Authors: | Mas-Moruno, C., Su, B., and Dalby, M. J. |
College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
Journal Name: | Advanced Healthcare Materials |
Publisher: | Wiley |
ISSN: | 2192-2640 |
ISSN (Online): | 2192-2659 |
Published Online: | 22 November 2018 |
Copyright Holders: | Copyright © 2019 The Authors |
First Published: | First published in Advanced Healthcare Materials 8(1):1801103 |
Publisher Policy: | Reproduced under a Creative Commons License |
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