Roxburgh, C. S. , Fenig, Y. M., Cercek, A., Shia, J., Rassam, R. M., Paty, P. B. and Nash, G. M. (2018) Outcomes of low-grade appendiceal mucinous neoplasms with remote acellular mucinous peritoneal deposits. Annals of Surgical Oncology, 26, pp. 118-124. (doi: 10.1245/s10434-018-7003-7) (PMID:30421044) (PMCID:PMC6339600)
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Abstract
Occasionally, low-grade appendiceal mucinous neoplasms (LAMN) present with mucinous peritoneal deposits (MPD) localized to periappendiceal tissue or diffused throughout the peritoneum. This study was aimed at evaluating the relevance of mucin cellularity for predicting outcomes of LAMN with remote MPD. The records of patients with LAMN and remote MPD who underwent initial assessment at a comprehensive cancer center from 1990 to 2015 were reviewed, and diagnostic procedures, treatments, and outcomes were analyzed. Of 48 patients included in the analysis, 19 had cellular MPD (CMPD) and 29 had acellular MPD. Of 33 patients who underwent cytoreductive surgery, 30 had a complete cytoreduction; the 3 patients with an incomplete cytoreduction had CMPD. In the follow-up period (median, 4 years), 6 patients died of the disease, all of whom had CMPD. Of 11 patients who had progression of disease, 10 had CMPD. Cellularity of remote MPD is an important determinant of disease outcome in LAMN. Approaches such as active surveillance may have a role in selected patients with LAMN and AMPD.
Item Type: | Articles |
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Additional Information: | This study was supported in part by Grant P30 CA008748 from the National Cancer Institute. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Roxburgh, Professor Campbell |
Authors: | Roxburgh, C. S., Fenig, Y. M., Cercek, A., Shia, J., Rassam, R. M., Paty, P. B., and Nash, G. M. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | Annals of Surgical Oncology |
Publisher: | Springer-Verlag |
ISSN: | 1068-9265 |
ISSN (Online): | 1534-4681 |
Copyright Holders: | Copyright © Society of Surgical Oncology 2018 |
First Published: | First published in Annals of Surgical Oncology 26:118-124 |
Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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