Signal interaction between the tumour and inflammatory cells in patients with gastrointestinal cancer: implications for treatment

Pennel, K. A.F., Park, J. H. , McMillan, D. C. , Roseweir, A. K. and Edwards, J. (2019) Signal interaction between the tumour and inflammatory cells in patients with gastrointestinal cancer: implications for treatment. Cellular Signalling, 54, pp. 81-90. (doi: 10.1016/j.cellsig.2018.11.013) (PMID:30453014)

Abstract

Over the last 15 years there has been a change in how we understand the impact of the interaction between the tumour and the host on cancer outcomes. From the simplistic view that the make-up of tumours cells largely determines their aggressiveness to a more complex view that the interaction between the products of tumour and host cell signal transduction pathways is crucial in determining whether the tumour cell is eliminated or survives in the host. Of the host cells, those with an immune/inflammatory function are most well documented to inhibit or promote tumour cell proliferation and dissemination. It is only in the last few years that there has been greater recognition of the impact of intracellular, cellular and systemic immune/inflammatory phenotypes on patient outcomes independent of current tumour staging and that these phenotypes are useful in informing oncological research and practice. In the present review we will examine the importance of inflammatory phenotypes at the intra-cellular, cellular and systemic levels on outcomes in patients with gastrointestinal cancer with focus on colorectal cancer. Based on these phenotypes we will examine and discuss the prospects for therapeutic intervention.

• Item Type: Articles
• Additional Information: This work was supported by the Medical Research Council.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Park, Mr James and Pennel, Miss Kathryn and McMillan, Professor Donald and Roseweir, Dr Antonia and Edwards, Professor Joanne
• Authors: Pennel, K. A.F., Park, J. H., McMillan, D. C., Roseweir, A. K., and Edwards, J.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Cellular Signalling
• Publisher: Elsevier
• ISSN: 0898-6568
• ISSN (Online): 1873-3913
• Published Online: 17 November 2018
• Copyright Holders: Copyright © 2018 Elsevier Inc.
• First Published: First published in Cellular Signalling 54: 81-90
• Publisher Policy: Reproduced in accordance with the publisher copyright policy