Land, S. C., Scott, C. L. and Walker, D. (2014) mTOR signalling, embryogenesis and the control of lung development. Seminars in Cell and Developmental Biology, 36, pp. 68-78. (doi: 10.1016/j.semcdb.2014.09.023) (PMID:25289569)
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Abstract
The existence of a nutrient sensitive “autocatakinetic” regulator of embryonic tissue growth has been hypothesised since the early 20th century, beginning with pioneering work on the determinants of foetal size by the Australian physiologist, Thorburn Brailsford-Robertson. We now know that the mammalian target of rapamycin complexes (mTORC1 and 2) perform this essential function in all eukaryotic tissues by balancing nutrient and energy supply during the first stages of embryonic cleavage, the formation of embryonic stem cell layers and niches, the highly specified programmes of tissue growth during organogenesis and, at birth, paving the way for the first few breaths of life. This review provides a synopsis of the role of the mTOR complexes in each of these events, culminating in an analysis of lung branching morphogenesis as a way of demonstrating the central role mTOR in defining organ structural complexity. We conclude that the mTOR complexes satisfy the key requirements of a nutrient sensitive growth controller and can therefore be considered as Brailsford-Robertson's autocatakinetic centre that drives tissue growth programmes during foetal development.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Walker, Dr David |
| Authors: | Land, S. C., Scott, C. L., and Walker, D. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Seminars in Cell and Developmental Biology |
| Publisher: | Elsevier |
| ISSN: | 1084-9521 |
| ISSN (Online): | 1096-3634 |
| Published Online: | 05 October 2014 |
| Copyright Holders: | Copyright © 2014 The Authors |
| First Published: | First published in Seminars in Cell and Developmental Biology 36: 68-78 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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