Turner, N. C.A., Connolly, J. P.R. and Roe, A. (2019) Control freaks-signals and cues governing the regulation of virulence in attaching and effacing pathogens. Biochemical Society Transactions, 47(1), pp. 229-238. (doi: 10.1042/BST20180546) (PMID:30559275) (PMCID:PMC6393859)
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Abstract
Enterohaemorrhagic Escherichia coli (EHEC) mediates disease using a type 3 secretion system (T3SS), which is encoded on the locus of enterocyte effacement (LEE) and is tightly controlled by master regulators. This system is further modulated by a number of signals that help to fine-tune virulence, including metabolic, environmental and chemical signals. Since the LEE, and its master regulator, Ler, were established there have been numerous scientific advancements in understanding the regulation and expression of virulence factors in EHEC. This review will discuss the recent advancements in this field since our previous review, with a focus on transcriptional regulation of the LEE.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Turner, Natasha and Connolly, Dr James and Roe, Professor Andrew |
| Authors: | Turner, N. C.A., Connolly, J. P.R., and Roe, A. |
| College/School: | College of Medical Veterinary and Life Sciences College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Biochemical Society Transactions |
| Publisher: | Portland Press |
| ISSN: | 0300-5127 |
| ISSN (Online): | 1470-8752 |
| Published Online: | 17 December 2018 |
| Copyright Holders: | Copyright © 2018 The Authors |
| First Published: | First published in Biochemical Society Transactions 47(1): 229-238 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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