Coelho, A.M., Cherubini, G., De Stefani, A., Negrin, A., Gutierrez-Quintana, R. , Bersan, E. and Guevar, J. (2019) Serological prevalence of toxoplasmosis and neosporosis in dogs diagnosed with suspected meningoencephalitis in the UK. Journal of Small Animal Practice, 60(1), pp. 44-50. (doi: 10.1111/jsap.12937) (PMID:30371939)
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Abstract
Objectives: To assess the prevalence of antibodies to Toxoplasma gondii and Neospora caninum in a population of dogs with a diagnosis of suspected inflammatory meningoencephalitis. Materials and Methods: Medical records of three referral centres were reviewed from 2008 to 2016 to identify a cohort of dogs diagnosed and treated for suspected inflammatory meningoencephalitis after testing for evidence of exposure to these pathogens. Results: In our sample of 400 dogs the prevalence for exposure (IgG>1:50) to Toxoplasma gondii was 8/201 (3∙98%). Active infection (IgG titre >1:400 or/and an IgM titre >1:64 and/or positive PCR in CSF) was suspected in 1/400 (0∙25%). The prevalence for exposure [Indirect fluorescent antibody (IFA) titre >1:50] and active infection (IFA titres ≥⃒1:400 and/or positive PCR in CSF) with Neospora caninum were 14/201 (6∙96%) and 9/400 (2∙25%), respectively. Clinical Significance: In view of the low prevalence of protozoan infections, the risk associated with starting immunosuppressive medication in dogs with evidence of inflammatory meningitis or encephalitis in the UK appears low.
| Item Type: | Articles |
|---|---|
| Additional Information: | The project was supported by the Clinical and Translational Science Award (CTSA) program, through the NIH National Center for Advancing Translational Sciences (NCATS), grant UL1TR002373. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Gutierrez Quintana, Mr Rodrigo |
| Authors: | Coelho, A.M., Cherubini, G., De Stefani, A., Negrin, A., Gutierrez-Quintana, R., Bersan, E., and Guevar, J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Journal Name: | Journal of Small Animal Practice |
| Publisher: | Wiley |
| ISSN: | 0022-4510 |
| ISSN (Online): | 1748-5827 |
| Published Online: | 29 October 2018 |
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