Cost-impact study of rotavirus vaccination programme in Scotland

Heggie, R., Murdoch, H., McIntosh, E. , Cameron, C., Smith-Palmer, A. and Bouttell, J. (2019) Cost-impact study of rotavirus vaccination programme in Scotland. Human Vaccines and Immunotherapeutics, 15(6), pp. 1265-1271. (doi: 10.1080/21645515.2018.1543522) (PMID:30395774)

173305.pdf - Accepted Version



Aim: In July 2013, the Scottish Government introduced a rotavirus vaccination programme into the childhood immunisation schedule. The aim of this research was to estimate the cost impact of this programme. Methods: Data for rotavirus-related resource use were identified including laboratory reports, hospitalisations, attendances at Accident and Emergency Departments, general practice consultations, calls to the National Health Service telephone helpline and prescriptions for common rehydration treatments. We used an interrupted time series analysis approach to assess the impact on resource utilisation in all categories. Appropriate costs were added to the models and predicted pre and post vaccination mean annual costs were estimated. The cost of the vaccination programme was estimated using costs from the literature. Results: The vaccination programme was associated with a reduction in utilisation in all measured healthcare resource categories. These reductions were all statistically significant (at the 95% level) with p-values less than 0.001. Reductions ranged from 18% in calls to NHS24 to 73% in positive laboratory reports. The vaccination programme was associated with a reduction in annual healthcare resource costs of 38% (£595,000 per 100,000 infants under five years old) in our measured categories (including £495,000 from a reduction in hospital stays). The annual overall cost-impact of the rotavirus vaccination programme (the cost of delivering the programme minus the reduction in resource costs) was estimated at approximately £435,000 per 100,000 infants under 5 years old. Conclusion: The rotavirus vaccination programme was associated with a reduction in all measured categories of rotavirus-related resource use by infants under 5 years old.

Item Type:Articles
Additional Information:Funded by Health Protection Scotland
Glasgow Author(s) Enlighten ID:Bouttell, Dr Janet and Heggie, Mr Robert and McIntosh, Professor Emma
Authors: Heggie, R., Murdoch, H., McIntosh, E., Cameron, C., Smith-Palmer, A., and Bouttell, J.
College/School:College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Health Economics and Health Technology Assessment
Journal Name:Human Vaccines and Immunotherapeutics
Publisher:Taylor & Francis
ISSN (Online):2164-554X
Published Online:05 November 2018
Copyright Holders:Copyright © 2018 Taylor and Francis Group, LLC
First Published:First published in Human Vaccines and Immunotherapeutics 15(6): 1265-1271
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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