Hussain, M., Baillie, G. , Gatherer, D. and Wilson, J.B. (2012) Investigating Molecular Interactions Between Epstein-Barr Virus Nuclear Antigen-1 and Partner Proteins. International Congress on Oncogenic Herpesviruses and Associated Diseases, Philadelphia, PA, USA, 01-05 Aug 2012.
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Abstract
EBNA1 is an essential viral latent protein required for viral genome maintenance and transactivation of certain viral genes. In addition, it contributes to apoptosis resistance of the virally infected cell. EBNA1 has been shown to interact with multiple cellular proteins, including the RNA processing protein EBP2, the ubiquitin specific protease USP7, and the kinase CK2. With a view to therapeutic disruption, in order to fine map the contact residues between these proteins we have first used in silico molecular modelling to build upon known crystal structures. Secondly we have employed peptides arrays; a rapid method of determining protein contact points, particularly useful for proteins difficult to crystalise or purify.
| Item Type: | Conference or Workshop Item |
|---|---|
| Status: | Published |
| Refereed: | No |
| Glasgow Author(s) Enlighten ID: | Wilson, Professor Joanna and Gatherer, Dr Derek and Baillie, Professor George |
| Authors: | Hussain, M., Baillie, G., Gatherer, D., and Wilson, J.B. |
| Subjects: | Q Science > QR Microbiology Q Science > QR Microbiology > QR355 Virology |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Life Sciences College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
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