Papalazarou, V., Salmeron-Sanchez, M. and Machesky, L. M. (2018) Tissue engineering the cancer microenvironment—challenges and opportunities. Biophysical Reviews, 10(6), pp. 1695-1711. (doi: 10.1007/s12551-018-0466-8) (PMID:30406572) (PMCID:PMC6297082)
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Abstract
Mechanosensing is increasingly recognised as important for tumour progression. Tumours become stiff and the forces that normally balance in the healthy organism break down and become imbalanced, leading to increases in migration, invasion and metastatic dissemination. Here, we review recent advances in our understanding of how extracellular matrix properties, such as stiffness, viscoelasticity and architecture control cell behaviour. In addition, we discuss how the tumour microenvironment can be modelled in vitro, capturing these mechanical aspects, to better understand and develop therapies against tumour spread. We argue that by gaining a better understanding of the microenvironment and the mechanical forces that govern tumour dynamics, we can make advances in combatting cancer dormancy, recurrence and metastasis.
| Item Type: | Articles |
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| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Salmeron-Sanchez, Professor Manuel and Machesky, Professor Laura and Papalazarou, Mr Vasileios |
| Authors: | Papalazarou, V., Salmeron-Sanchez, M., and Machesky, L. M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences College of Medical Veterinary and Life Sciences > School of Molecular Biosciences College of Science and Engineering > School of Engineering College of Science and Engineering > School of Engineering > Biomedical Engineering |
| Journal Name: | Biophysical Reviews |
| Publisher: | Springer |
| ISSN: | 1867-2450 |
| ISSN (Online): | 1867-2469 |
| Published Online: | 08 November 2018 |
| Copyright Holders: | Copyright © 2018 The Authors |
| First Published: | First published in Biophysical Reviews 10(6):1695-1711 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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