Mesenchymal stem cell-derived extracellular vesicles may promote breast cancer cell dormancy

Casson, J., Davies, O. G., Smith, C.-A. , Dalby, M. J. and Berry, C. C. (2018) Mesenchymal stem cell-derived extracellular vesicles may promote breast cancer cell dormancy. Journal of Tissue Engineering, 9, p. 2041731418810093. (doi: 10.1177/2041731418810093) (PMID:30627418) (PMCID:PMC6311537)

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Disseminated breast cancer cells have the capacity to metastasise to the bone marrow and reside in a dormant state within the mesenchymal stem cell niche. Research has focussed on paracrine signalling factors, such as soluble proteins, within the microenvironment. However, it is now clear extracellular vesicles secreted by resident mesenchymal stem cells into this microenvironment also play a key role in the initiation of dormancy. Dormancy encourages reduced cell proliferation and migration, while upregulating cell adhesion, thus retaining the cancer cells within the bone marrow microenvironment. Here, MCF7 breast cancer cells were treated with mesenchymal stem cell–derived extracellular vesicles, resulting in reduced migration in two-dimensional and three-dimensional culture, with reduced cell proliferation and enhanced adhesion, collectively supporting cancer cell dormancy.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Berry, Dr Catherine and Dalby, Professor Matthew and Casson, Jake and Smith, Mrs Carol-Anne
Authors: Casson, J., Davies, O. G., Smith, C.-A., Dalby, M. J., and Berry, C. C.
College/School:College of Medical Veterinary and Life Sciences > School of Molecular Biosciences
Journal Name:Journal of Tissue Engineering
Publisher:SAGE Publications
ISSN (Online):2041-7314
Published Online:25 December 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Journal of Tissue Engineering 9: 2041731418810093
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
619691Nanoparticles and nanotopography: a nano-toolbox to control stem cell self-renewal via microRNAsCatherine BerryBiotechnology and Biological Sciences Research Council (BBSRC)BB/L008661/1RI MOLECULAR CELL & SYSTEMS BIOLOGY