Tiemann, L., Hohn, V. D., Ta Dinh, S., May, E. S., Nickel, M. M., Gross, J. and Ploner, M. (2018) Distinct patterns of brain activity mediate perceptual and motor and autonomic responses to noxious stimuli. Nature Communications, 9, 4487. (doi: 10.1038/s41467-018-06875-x) (PMID:30367033) (PMCID:PMC6203833)
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Abstract
Pain is a complex phenomenon involving perceptual, motor, and autonomic responses, but how the brain translates noxious stimuli into these different dimensions of pain is unclear. Here, we assessed perceptual, motor, and autonomic responses to brief noxious heat stimuli and recorded brain activity using electroencephalography (EEG) in humans. Multilevel mediation analysis reveals that each pain dimension is subserved by a distinct pattern of EEG responses and, conversely, that each EEG response differentially contributes to the different dimensions of pain. In particular, the translation of noxious stimuli into autonomic and motor responses involved the earliest N1 wave, whereas pain perception was mediated by later N2 and P2 waves. Gamma oscillations mediated motor responses rather than pain perception. These findings represent progress towards a mechanistic understanding of the brain processes translating noxious stimuli into pain and suggest that perceptual, motor, and autonomic dimensions of pain are partially independent rather than serial processes.
| Item Type: | Articles |
|---|---|
| Additional Information: | The study was supported by the Deutsche Forschungsgemeinschaft (PL 321/11–1, PL 321/11-2, and PL 321/13-1), the Bavarian State Ministry of Education, Science and the Arts, and the Wellcome Trust (098433). |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Gross, Professor Joachim |
| Authors: | Tiemann, L., Hohn, V. D., Ta Dinh, S., May, E. S., Nickel, M. M., Gross, J., and Ploner, M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience |
| Journal Name: | Nature Communications |
| Publisher: | Nature Publishing Group |
| ISSN: | 2041-1723 |
| ISSN (Online): | 2041-1723 |
| Copyright Holders: | Copyright © 2018 The Authors |
| First Published: | First published in Nature Communications 9: 4487 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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