The presentation, management and outcome of inflammatory breast cancer cases in the UK: data from a multi-centre retrospective review

Copson, E. et al. (2018) The presentation, management and outcome of inflammatory breast cancer cases in the UK: data from a multi-centre retrospective review. Breast, 42, pp. 133-141. (doi: 10.1016/j.breast.2018.09.003) (PMID:30278369)

169455.pdf - Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.



Objectives: Inflammatory Breast cancer (IBC) is a rare but aggressive form of breast cancer. Its incidence and behaviour in the UK is poorly characterised. We collected retrospective data from hospitals in the UK and Ireland to describe the presentation, pathology, treatment and clinical course of IBC in the UK. Materials and methods: Patients with IBC diagnosed between 1997–2014 at fourteen UK and Irish hospitals were identified from local breast unit databases. Patient characteristics, tumour pathology and stage, and details of surgical, systemic and radiotherapy treatment and follow-up data were collected from electronic patient records and medical notes. Result: This retrospective review identified 445 patients with IBC accounting for 0.4–1.8% of invasive breast cancer cases. Median follow-up was 4.2 years. 53.2% of tumours were grade 3, 56.2% were oestrogen receptor positive, 31.3% were HER2 positive and 25.1% were triple negative. 20.7% of patients had distant metastases at presentation. Despite trimodality treatment in 86.4%, 40.1% of stage III patients developed distant metastases. Five-year overall survival (OS) was 61.0% for stage III and 21.4% for stage IV patients. Conclusions: This is the largest series of UK IBC patients reported to date. It indicates a lower incidence than in American series, but confirms that IBC has a high risk of recurrence with poor survival despite contemporary multi-modality therapy. A national strategy is required to facilitate translational research into this aggressive disease.

Item Type:Articles
Glasgow Author(s) Enlighten ID:MacPherson, Professor Iain
Authors: Copson, E., Shaaban, A.M., Maishman, T., Moseley, P.M., McKenzie, H., Bradbury, J., Borley, A., Brzezinska, M., Chan, S.Y.T., Ching, J., Cutress, R.I., Danial, I., Dall, B., Kerin, M., Lowery, A.J., Macpherson, I.R., Romics, L., Sawyer, E., Sharmat, N., Sircar, T., Vidya, R., Pan, Y., Rea, D., Jones, L., Eccles, D.M., and Berditchevski, F.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:Breast
ISSN (Online):1532-3080
Published Online:15 September 2018
Copyright Holders:Copyright © 2018 Elsevier Ltd.
First Published:First published in Breast 242: 133-141
Publisher Policy:Reproduced in accordance with the publisher copyright policy

University Staff: Request a correction | Enlighten Editors: Update this record