Role of ubiquitylation in controlling suppressor of cytokine signalling 3 (SOCS3) function and expression

Williams, J., Munro, K. and Palmer, T. (2014) Role of ubiquitylation in controlling suppressor of cytokine signalling 3 (SOCS3) function and expression. Cells, 3(2), pp. 546-562. (doi: 10.3390/cells3020546) (PMID:24886706) (PMCID:PMC4092859)

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Abstract

The realisation that unregulated activation of the Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathway is a key driver of a wide range of diseases has identified its components as targets for therapeutic intervention by small molecule inhibitors and biologicals. In this review, we discuss JAK-STAT signalling pathway inhibition by the inducible inhibitor “suppressor of cytokine signaling 3 (SOCS3), its role in diseases such as myeloproliferative disorders, and its function as part of a multi-subunit E3 ubiquitin ligase complex. In addition, we highlight potential applications of these insights into SOCS3-based therapeutic strategies for management of conditions such as vascular re-stenosis associated with acute vascular injury, where there is strong evidence that multiple processes involved in disease progression could be attenuated by localized potentiation of SOCS3 expression levels.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Palmer, Dr Timothy and MUNRO, KIRSTEN and Williams, Dr Jamie
Authors: Williams, J., Munro, K., and Palmer, T.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
College of Medical Veterinary and Life Sciences > School of Molecular Biosciences
Journal Name:Cells
Publisher:MDPI
ISSN:2073-4409
ISSN (Online):2073-4409
Copyright Holders:Copyright © 2014 The Authors
First Published:First published in Cells 3(2):546-562
Publisher Policy:Reproduced under a Creative Commons License

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