Fletcher, A., McLoone, P. and Bulpitt, C. (1988) Quality of life on angina therapy: a randomised controlled trial of transdermal glyceryl trinitrate against placebo. Lancet, 2(8601), pp. 4-8. (doi: 10.1016/S0140-6736(88)92942-X) (PMID:2898636)
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Abstract
In a randomised controlled trial in 427 men with chronic stable angina continuous use of 5 mg transdermal glyceryl trinitrate (GTN) showed no advantage over placebo in terms of efficacy (anginal attack rates and sublingual GTN consumption) or quality of life (as measured with the sickness impact profile and a health index of disability). Patients on the active drug reported headaches more frequently than patients on placebo, and a higher proportion of them withdrew from the trial because of headache. Quality-of-life measurements showed a significant adverse effect of active treatment, principally in the social interaction dimension of the sickness impact profile. A similar effect was observed in placebo patients when crossed to active treatment in a 4-week single-blind period. The results suggest no benefit in the relief of chest pain from 5 mg transdermal GTN when used continuously.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | McLoone, Mr Philip |
| Authors: | Fletcher, A., McLoone, P., and Bulpitt, C. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health |
| Journal Name: | Lancet |
| Publisher: | The Lancet Publishing Group |
| ISSN: | 0140-6736 |
| ISSN (Online): | 1474-547X |
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