The relationship between tumour glucose metabolism and host systemic inflammatory responses in patients with cancer: a systematic review

Dolan, R. D. , McLees, N. G., Irfan, A., McSorley, S. T. , Horgan, P. G. , Colville, D. and McMillan, D. C. (2019) The relationship between tumour glucose metabolism and host systemic inflammatory responses in patients with cancer: a systematic review. Journal of Nuclear Medicine, 60(4), pp. 467-471. (doi: 10.2967/jnumed.118.216697) (PMID:30166353)

Abstract

One of the most important and long recognised characteristics of tumour cells is their dysregulated cellular energetics with anaerobic driven glucose uptake. In patients with cancer the prognostic value of the systemic inflammatory response has been well established and the recent combination of PET and CT scanning combines the assessment of tumour physiological activity with detailed anatomical localisation. The aim of this study was to carry out a systematic review of the assessment of the relationship between both the tumour and host inflammatory responses using PETCT. An extensive literature review using targeted subject headings was carried out in the US National Library of Medicine, the Excerpta Medica database and Cochrane Database of Systematic Reviews until the 31st March 2018. On completion of the online search, the title and abstracts of each identified study was examined for relevance. Studies with duplicate datasets, not available in English and that did not have full text availability were excluded. Full texts of relevant articles were obtained and were then examined to identify any further relevant articles. Twelve studies containing 2,588 patients were included in the final analysis. All of the included studies used the FDG tracer in PETCT imaging and had biochemical assessment of the systemic inflammatory response. The majority of studies showed a direct relationship between the tumour and bone marrow glucose uptake and host systemic inflammatory responses as measured by C-Reactive Protein (CRP) ( = 2), albumin ( = 2), White Cell Count (WCC) ( = 3), neutrophils ( = 2) and platelets ( = 2). The majority of the studies ( = 8) also showed a direct relationship between tumour and bone marrow glucose uptake and poor outcomes. This review suggests a direct relationship between the tumour and bone marrow glucose uptake and host systemic inflammation. This may suggest new approaches for more optimal therapeutic targeting and monitoring strategies in patients with cancer.

• Item Type: Articles
• Keywords: Cancer, Glasgow Prognostic Score, oncology: general, other, overall survival, PET/CT, positron emission tomography/computed tomography, systemic inflammation.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Horgan, Professor Paul and McSorley, Dr Stephen and Colville, Dr Dave and McMillan, Professor Donald and Irfan, Dr Ahmer and Dolan, Dr Ross
• Authors: Dolan, R. D., McLees, N. G., Irfan, A., McSorley, S. T., Horgan, P. G., Colville, D., and McMillan, D. C.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Journal of Nuclear Medicine
• Publisher: Society of Nuclear Medicine
• ISSN: 0161-5505
• ISSN (Online): 2159-662X
• Published Online: 30 August 2018
• Copyright Holders: Copyright © 2019 Society of Nuclear Medicine and Molecular Imaging
• First Published: First published in Journal of Nuclear Medicine 60(4): 467-471
• Publisher Policy: Reproduced in accordance with the publisher copyright policy