Aggarwal, A. (2018) Determination of prestress and elastic properties of virus capsids. Physical Review E, 97, 032414. (doi: 10.1103/PhysRevE.97.032414) (PMID:29776150)
|
Text
168871.pdf - Accepted Version 5MB |
Abstract
Virus capsids are protein shells that protect the virus genome, and determination of their mechanical properties has been a topic of interest because of their potential use in nanotechnology and therapeutics. It has been demonstrated that stresses exist in virus capsids, even in their equilibrium state, due to their construction. These stresses, termed “prestresses” in this study, closely affect the capsid's mechanical behavior. Three methods—shape-based metric, atomic force microscope indentation, and molecular dynamics—have been proposed to determine the capsid elastic properties without fully accounting for prestresses. In this paper, we theoretically analyze the three methods used for mechanical characterization of virus capsids and numerically investigate how prestresses affect the capsid's mechanical properties. We consolidate all the results and propose that by using these techniques collectively, it is possible to accurately determine both the mechanical properties and prestresses in capsids.
| Item Type: | Articles |
|---|---|
| Additional Information: | This work was supported by Welsh Government and Higher Education Funding Council for Wales through the Sêr Cymru National Research Network in Advanced Engineering and Materials (Grant No. F28), and the Engineering and Physical Sciences Research Council of the UK (Grant No. EP/P018912/1). |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Aggarwal, Dr Ankush |
| Authors: | Aggarwal, A. |
| College/School: | College of Science and Engineering > School of Engineering > Infrastructure and Environment |
| Journal Name: | Physical Review E |
| Publisher: | American Physical Society |
| ISSN: | 1539-3755 |
| ISSN (Online): | 1550-2376 |
| Copyright Holders: | Copyright © 2018 American Physical Society |
| First Published: | First published in Physical Review E |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
University Staff: Request a correction | Enlighten Editors: Update this record
Deposit and Record Details
Deposit and Record Details