Grent-‘t-Jong, T. et al. (2018) Resting-state gamma-band power alterations in schizophrenia reveal functional E/I-balance abnormalities across illness-stages. eLife, 7, e37799. (doi: 10.7554/eLife.37799) (PMID:30260771) (PMCID:PMC6160226)
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Abstract
We examined alterations in E/I-balance in schizophrenia (ScZ) through measurements of resting-state gamma-band activity in participants meeting clinical high-risk (CHR) criteria (n = 88), 21 first episode (FEP) patients and 34 chronic ScZ-patients. Furthermore, MRS-data were obtained in CHR-participants and matched controls. Magnetoencephalographic (MEG) resting-state activity was examined at source level and MEG-data were correlated with neuropsychological scores and clinical symptoms. CHR-participants were characterized by increased 64–90 Hz power. In contrast, FEP- and ScZ-patients showed aberrant spectral power at both low- and high gamma-band frequencies. MRS-data showed a shift in E/I-balance toward increased excitation in CHR-participants, which correlated with increased occipital gamma-band power. Finally, neuropsychological deficits and clinical symptoms in FEP and ScZ-patients were correlated with reduced gamma band-activity, while elevated psychotic symptoms in the CHR group showed the opposite relationship. The current study suggests that resting-state gamma-band power and altered Glx/GABA ratio indicate changes in E/I-balance parameters across illness stages in ScZ.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Uhlhaas, Professor Peter and Goense, Dr Jozien and Grent-'T-Jong, Dr Tineke and Gajwani, Dr Ruchika and Gross, Professor Joachim and Gumley, Professor Andrew |
Creator Roles: | Grent-'T-Jong, T.Conceptualization, Software, Formal analysis, Methodology, Writing – original draft, Writing – review and editing Gross, J.Formal analysis, Funding acquisition, Writing – original draft Goense, J.Formal analysis, Writing – original draft Gajwani, R.Project administration Gumley, A. I.Funding acquisition Uhlhaas, P. J.Conceptualization, Supervision, Funding acquisition, Methodology, Writing – original draft, Project administration, Writing – review and editing |
Authors: | Grent-‘t-Jong, T., Gross, J., Goense, J., Wibral, M., Gajwani, R., Gumley, A. I., Lawrie, S. M., Schwannauer, M., Schultze-Lutter, F., Navarro Schröder, T., Koethe, D., Leweke, M. F., Singer, W., and Uhlhaas, P. J. |
College/School: | College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Mental Health and Wellbeing College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience |
Journal Name: | eLife |
Publisher: | eLife Sciences Publications |
ISSN: | 2050-084X |
ISSN (Online): | 2050-084X |
Copyright Holders: | Copyright © 2018 Grent-‘t-Jong et al. |
First Published: | First published in eLife 7: e37799 |
Publisher Policy: | Reproduced under a Creative Commons License |
Data DOI: | 10.5061/dryad.vn23kb7 |
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