Efficacy of subcutaneous secukinumab in patients with active psoriatic arthritis atratified by prior tumor necrosis factor inhibitor use: results from the randomized placebo-controlled FUTURE 2 study

Kavanaugh, A., McInnes, I. B. , Mease, P. J., Hall, S., Chinoy, H., Kivitz, A. J., Wang, Z. and Mpofu, S. (2016) Efficacy of subcutaneous secukinumab in patients with active psoriatic arthritis atratified by prior tumor necrosis factor inhibitor use: results from the randomized placebo-controlled FUTURE 2 study. Journal of Rheumatology, 43(9), pp. 1713-1717. (doi: 10.3899/jrheum.160275) (PMID:27307536)

Abstract

Objective. To determine the effect of prior tumor necrosis factor inhibitor (TNFi) therapy on secukinumab efficacy in psoriatic arthritis (PsA). Methods. Patients were randomized to secukinumab 300 mg, 150 mg, 75 mg, or placebo. Results. American College of Rheumatology 20 responses at Week 24 with secukinumab 300 mg, 150 mg, 75 mg, and placebo were 58.2%, 63.5%, 36.9%, and 15.9% in TNFi-naive (n = 258), and 45.5%, 29.7%, 14.7%, and 14.3% in TNFi-exposed patients (n = 139), respectively. Week 52 responses with secukinumab 300 mg, 150 mg, and 75 mg were 68.7%, 79.4%, and 58.5% in TNFi-naive, and 54.5%, 37.8%, and 35.3% in TNFi-exposed patients, respectively. Conclusion. Secukinumab was efficacious in TNFi-naive and TNFi-exposed patients with PsA, with greatest improvements in TNFi-naive patients.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: McInnes, Professor Iain
• Authors: Kavanaugh, A., McInnes, I. B., Mease, P. J., Hall, S., Chinoy, H., Kivitz, A. J., Wang, Z., and Mpofu, S.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: Journal of Rheumatology
• Publisher: Journal of Rheumatology
• ISSN: 0315-162X
• ISSN (Online): 1499-2752
• Published Online: 01 September 2016