Panagiotou, N. , Neytchev, O. , Selman, C. and Shiels, P. G. (2018) Extracellular vesicles, ageing, and therapeutic interventions. Cells, 7(8), 110. (doi: 10.3390/cells7080110) (PMID:30126173) (PMCID:PMC6115766)
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Abstract
A more comprehensive understanding of the human ageing process is required to help mitigate the increasing burden of age-related morbidities in a rapidly growing global demographic of elderly individuals. One exciting novel strategy that has emerged to intervene involves the use of extracellular vesicles to engender tissue regeneration. Specifically, this employs their molecular payloads to confer changes in the epigenetic landscape of ageing cells and ameliorate the loss of functional capacity. Understanding the biology of extracellular vesicles and the specific roles they play during normative ageing will allow for the development of novel cell-free therapeutic interventions. Hence, the purpose of this review is to summarise the current understanding of the mechanisms that drive ageing, critically explore how extracellular vesicles affect ageing processes and discuss their therapeutic potential to mitigate the effects of age-associated morbidities and improve the human health span.
Item Type: | Articles |
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Additional Information: | N.P. was funded by a studentship award from the Biotechnology and Biological Sciences Research Council (BBSRC) to P.G.S. and C.S. O.N. was funded by an IPP from UoG (University of Glasgow) and Constant Pharma Ltd. award to P.G.S. and C.S. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Selman, Professor Colin and Panagiotou, Dr Nikolaos and Neytchev, Ognian and Shiels, Professor Paul |
Authors: | Panagiotou, N., Neytchev, O., Selman, C., and Shiels, P. G. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
Journal Name: | Cells |
Publisher: | MDPI |
ISSN: | 2073-4409 |
ISSN (Online): | 2073-4409 |
Copyright Holders: | Copyright © 2018 The Authors |
First Published: | First published in Cells 7(8):110 |
Publisher Policy: | Reproduced under a Creative Commons License |
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