Donnelly, H., Salmeron-Sanchez, M. and Dalby, M. J. (2018) Designing stem cell niches for differentiation and self-renewal. Journal of the Royal Society: Interface, 15(145), 20180388. (doi: 10.1098/rsif.2018.0388) (PMID:30158185) (PMCID:PMC6127175)
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Abstract
Mesenchymal stem cells, characterized by their ability to differentiate into skeletal tissues and self-renew, hold great promise for both regenerative medicine and novel therapeutic discovery. However, their regenerative capacity is retained only when in contact with their specialized microenvironment, termed the stem cell niche. Niches provide structural and functional cues that are both biochemical and biophysical, stem cells integrate this complex array of signals with intrinsic regulatory networks to meet physiological demands. Although, some of these regulatory mechanisms remain poorly understood or difficult to harness with traditional culture systems. Biomaterial strategies are being developed that aim to recapitulate stem cell niches, by engineering microenvironments with physiological-like niche properties that aim to elucidate stem cell-regulatory mechanisms, and to harness their regenerative capacity in vitro. In the future, engineered niches will prove important tools for both regenerative medicine and therapeutic discoveries.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Salmeron-Sanchez, Professor Manuel and Dalby, Professor Matthew and Donnelly, Dr Hannah |
| Authors: | Donnelly, H., Salmeron-Sanchez, M., and Dalby, M. J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences College of Science and Engineering > School of Engineering > Biomedical Engineering |
| Journal Name: | Journal of the Royal Society: Interface |
| Publisher: | The Royal Society |
| ISSN: | 1742-5689 |
| ISSN (Online): | 1742-5662 |
| Published Online: | 29 August 2018 |
| Copyright Holders: | Copyright © 2018 The Authors |
| First Published: | First published in Journal of the Royal Society: Interface 15(145):20180388 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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