Ma, Y. et al. (2019) Identification of fukinolic acid from Cimicifuga heracleifolia and its derivatives as novel antiviral compounds against enterovirus A71 infection. International Journal of Antimicrobial Agents, 53(2), pp. 128-136. (doi: 10.1016/j.ijantimicag.2018.07.014) (PMID:30063999)
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166770.pdf - Accepted Version Available under License Creative Commons Attribution Non-commercial No Derivatives. 1MB |
Abstract
Human enterovirus 71 (EV-A71) infections cause a wide array of diseases ranging from diarrhoea and rashes to hand-foot-and-mouth disease and, in rare cases, severe neurological disorders. No specific antiviral drug therapy is currently available. Extracts from seventy-five Chinese medicinal plants selected for antiviral activity based on the Chinese pharmacopeia and advice from traditional Chinese medicine clinicians were tested for activity against EV-A71. The aqueous extract of the rhizome of Cimicifuga heracleifolia (Sheng Ma) and Arnebia euchroma (Zi Cao) showed potent antiviral activity. The active fractions were isolated by bioassay-guided purification, and identified by a combination of high-resolution mass spectrometry and NMR. Fukinolic acid and cimicifugic acid A and J, were identified as active anti-EV-A71 compounds for Cimicifuga heracleifolia, whereas for Arnebia euchroma, two caffeic acid derivatives were tentatively deduced. Commercially available fukinolic acid analogues like L-chicoric acid and D-chicoric also showed in vitro micromolar activity against EV-A71 lab-strain and clinical isolates.
| Item Type: | Articles |
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| Additional Information: | Wenjuan Cong and Hao Huang were supported by grants of the Bilateral Scientific Cooperation between Tsinghua University Beijing and the KU Leuven (BIL10/20T and BIL/09/011). Yipeng Ma was supported by a scholarship of the Chinese Scholarship Council. Walter Luyten largely supported himself. |
| Keywords: | Arnebia euchroma, Cimicifuga heracleifolia, Cimicifugic acid, enterovirus 71, fukinolic acid, traditional Chinese medicine. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Cong, Dr Wenjuan |
| Authors: | Ma, Y., Cong, W., Huang, H., Sun, L., Mai, A. H., Boonen, K., Maryam, W., De Borggraeve, W., Luo, G., Liu, Q., Schoofs, L., Van Kuppeveld, F., Neyts, J., Mirabelli, C., and Luyten, W. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | International Journal of Antimicrobial Agents |
| Publisher: | Elsevier |
| ISSN: | 0924-8579 |
| ISSN (Online): | 1872-7913 |
| Published Online: | 29 July 2018 |
| Copyright Holders: | Copyright © 2018 Elsevier B.V. and International Society of Chemotherapy |
| First Published: | First published in International Journal of Antimicrobial Agents 53(2): 128-136 |
| Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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