Withdrawal of antihypertensive therapy in people with dementia: feasibility study

van der Wardt, V., Burton, J. K. , Conroy, S., Welsh, T., Logan, P., Taggar, J., Tanajewski, L. and Gladman, J. (2018) Withdrawal of antihypertensive therapy in people with dementia: feasibility study. Pilot and Feasibility Studies, 4, 29. (doi: 10.1186/s40814-017-0221-0) (PMID:29340166) (PMCID:PMC5759798)

Abstract

Background: This study explored the feasibility of a randomised controlled withdrawal trial of antihypertensive medication in normotensive people with dementia. Feasibility aspects included response, recruitment, exclusion and drop-out rates, suitability of outcome measures, acceptability of study procedures and an indicative economic evaluation for a randomised controlled trial. Methods: A cohort study attempting the withdrawal of antihypertensive drugs where appropriate and a feasibility study of home-based blood pressure monitoring, in people with dementia treated for hypertension, was undertaken. Interviews with participants and carers and an indicative economic evaluation were also undertaken. Results: Three hundred and sixty-two primary care practices in the East Midlands were contacted of which only 41 (11% (95%CI 8–15%)) agreed to support the study. These 41 practices posted 940 letters to potential participants. Thirty participants were enrolled in the cohort study of whom 9 were eligible for the antihypertensive withdrawal programme, 20 participated in a home blood pressure monitoring sub-group analysis and 12 took part in an interview study. Twenty-two of those enrolled in the cohort study were followed up at 6 months. The withdrawal programme was acceptable to participants and general practitioners (GPs). The study procedures including assessments and home blood pressure monitoring were acceptable to the participants and their carers. The economic evaluation was not possible. Conclusion: A withdrawal trial of antihypertensive medication in normotensive people with dementia may not be feasible in the UK because of low recruitment rates.

• Item Type: Articles
• Additional Information: This paper/abstract/presentation etc. presents independent research funded by the National Institute for Health Research (NIHR) under its Research for Patient Benefit (RfPB) Programme (Grant Reference Number PB-PG-1112-29,070). The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Burton, Dr Jenni
• Authors: van der Wardt, V., Burton, J. K., Conroy, S., Welsh, T., Logan, P., Taggar, J., Tanajewski, L., and Gladman, J.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Pilot and Feasibility Studies
• Publisher: BioMed Central
• ISSN: 2055-5784
• ISSN (Online): 2055-5784
• Copyright Holders: Copyright © 2018 The Authors
• First Published: First published in Pilot and Feasibility Studies 4:29
• Publisher Policy: Reproduced under a Creative Commons License