Role of adiponectin in matching of fetal and placental weight in mothers with type 1 diabetes

Nelson, S., Freeman, D.J. , Sattar, N. and Lindsay, R.S. (2008) Role of adiponectin in matching of fetal and placental weight in mothers with type 1 diabetes. Diabetes Care, 31(6), pp. 1123-1125. (doi: 10.2337/dc07-2195)

Abstract

OBJECTIVE—To assess the association of fetal hormones with placental growth and fetal weight–to–placental weight ratio index (FPI) in pregnancies complicated by maternal diabetes. RESEARCH DESIGN AND METHODS—We conducted a prospective study using umbilical venous blood samples taken at birth from 122 offspring of mothers with type 1 diabetes (OT1D) and 46 control subjects. RESULTS—Placental weight (P = 0.009) and gestation-adjusted birth weight (P < 0.001) were increased in OT1D, but FPI was unaltered (P = 0.33). Placental weight correlated with birth weight (P < 0.001) and cord leptin (P < 0.001) in control subjects and OT1D, with further relationships with cord insulin, IGF-1, IGF-binding protein-3 (IGFBP-3), and triceps and subscapular thickness in OT1D. FPI was associated with adiponectin in both groups, even after adjustment for confounders. CONCLUSIONS—Placental and fetal growth show a parallel increase in mothers with type 1 diabetes. The possible role of adiponectin in matching of fetal and placental growth merits further study.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Lindsay, Dr Robert and Nelson, Professor Scott and Freeman, Dr Dilys and Sattar, Professor Naveed
• Authors: Nelson, S., Freeman, D.J., Sattar, N., and Lindsay, R.S.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities
• Journal Name: Diabetes Care
• Publisher: American Diabetes Association
• ISSN: 1935-5548
• ISSN (Online): 0149-5992