Use of the Litomosoides sigmodontis infection model of filariasis to study type 2 immunity

Fulton, A., Babayan, S.A. and Taylor, M.D. (2018) Use of the Litomosoides sigmodontis infection model of filariasis to study type 2 immunity. In: Reinhardt, R. L. (ed.) Type 2 Immunity: Methods and Protocols. Series: Methods in molecular biology (1799). Humana Press: New York, NY, pp. 11-26. ISBN 9781493978953 (doi: 10.1007/978-1-4939-7896-0_2)

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Helminth parasites infect over 2 billion people worldwide resulting in huge global health and economic burden. Helminths typically stimulate Type 2 immune responses and excel at manipulating or suppressing host-immune responses resulting in chronic infections that can last for years to decades. Alongside the importance for the development of helminth treatments and vaccines, studying helminth immunity has unraveled many fundamental aspects of Type 2 immunity and immune regulation with implications for the treatment of autoimmunity and Type 2-mediated diseases, such as allergies. Here we describe the maintenance and use of Litomosoides sigmodontis, a murine model for studying host-parasite interactions, Type 2 immunity, and vaccines to tissue-dwelling filarial nematodes, which in humans cause lymphatic filariasis (e.g., Brugia malayi) and onchocerciasis (Onchocerca volvulus).

Item Type:Book Sections
Keywords:Filariasis, helminth, infection model, parasite, type 2 immunity.
Glasgow Author(s) Enlighten ID:Babayan, Dr Simon
Authors: Fulton, A., Babayan, S.A., and Taylor, M.D.
College/School:College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
Publisher:Humana Press
Published Online:29 June 2018

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