The relationship between computed tomography‐derived body composition, systemic inflammatory response, and survival in patients undergoing surgery for colorectal cancer

Dolan, R. , Almasaudi, A. S., Dieu, L. B., Horgan, P. G. , McSorley, S. T. and McMillan, D. C. (2019) The relationship between computed tomography‐derived body composition, systemic inflammatory response, and survival in patients undergoing surgery for colorectal cancer. Journal of Cachexia, Sarcopenia and Muscle, 10(1), pp. 111-122. (doi: 10.1002/jcsm.12357) (PMID:30460764) (PMCID:PMC6438413)

Abstract

Introduction: Colorectal cancer (CRC) is the fourth leading cause of cancer mortality in developed countries. There is evidence supporting a disproportionate loss of skeletal muscle as an independent prognostic factor. The importance of the systemic inflammatory response (SIR) as a unifying mechanism for specific loss of skeletal muscle mass in patients with cancer is increasingly recognised. The aim of the present study was to delineate the relationship between the SIR, skeletal muscle index (SMI), skeletal muscle density (SMD) and overall survival in patients with colorectal cancer. Patients and Methods: The study included 650 patients with primary operable colorectal cancer. CT scans were used to define the presence of visceral obesity (VO), sarcopenia (low SMI) and myosteatosis (low SMD). Tumour and patient characteristics were recorded. Survival analysis was carried out using univariate and multivariate Cox regression. Results: A total of 650 patients (354 males, 296 females) were included. The majority of patients were over 65 years of age (64%) and overweight or obese (68%). On univariate survival analysis, age, ASA, TNM stage, mGPS, BMI, SFI, VO, SMI and SMD were significantly associated with overall survival (all p<0.05). A low SMI and SMD were significantly associated with an elevated mGPS (<0.05). On multivariate analysis, SMI (Martin) (HR 1.50, 95%CI 1.04-2.18, p=0.031), SMD (Xiao) (HR 1.42, 95%CI 0.98-2.05, p=0.061) and mGPS (HR 1.44, 95%CI 1.15-1.79, p=0.001) were independently associated with overall survival. SMD but not SMI was significantly associated with ASA (P<0.001). Conclusions: This study delineates the relationship between the loss of quantity and quality of skeletal muscle mass, the systemic inflammatory response and survival in patients with operable colorectal cancer.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Horgan, Professor Paul and McMillan, Professor Donald and McSorley, Dr Stephen and Almasaudi, Arwa and Dolan, Dr Ross
• Authors: Dolan, R., Almasaudi, A. S., Dieu, L. B., Horgan, P. G., McSorley, S. T., and McMillan, D. C.
• College/School: College of Medical Veterinary and Life Sciences; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Journal of Cachexia, Sarcopenia and Muscle
• Publisher: Wiley
• ISSN: 2190-5991
• ISSN (Online): 2190-6009
• Published Online: 20 November 2018
• Copyright Holders: Copyright © 2018 The Authors
• First Published: First published in Journal of Cachexia, Sarcopenia and Muscle 10(1): 111-122
• Publisher Policy: Reproduced under a Creative Commons License