Determinants of achieved LDL cholesterol and "Non-HDL" cholesterol in the management of dyslipidemias

Packard, C. J. (2018) Determinants of achieved LDL cholesterol and "Non-HDL" cholesterol in the management of dyslipidemias. Current Cardiology Reports, 20(8), 60. (doi: 10.1007/s11886-018-1003-x) (PMID:29904807)

Abstract

Purpose of Review: The advent of combination therapy to provide LDL lowering beyond that achieved with statins necessitates the development of greater understanding of how drugs work together, what changes occur in key lipoprotein fractions, and what residual risk remains. Recent Findings: Clinical trials of agents that, when added to statins, generate profound LDL lowering have been successful in reducing further the risk of cardiovascular disease. LDL cholesterol can be now decreased to unprecedented levels, so the focus of attention then shifts to other apolipoprotein B-containing, atherogenic lipoprotein classes such as lipoprotein(a) and remnants of the metabolism of triglyceride-rich particles. “Non-HDL cholesterol” is used increasingly (especially if measured in the non-fasting state) as a more comprehensive index of risk. Summary: Metabolic studies reveal how current drugs act in combination to achieve profound lipid lowering. However, care is needed in interpreting achieved LDLc and non-HDLc levels in the emerging treatment paradigm.

• Item Type: Articles
• Keywords: CVD prevention, clinical trials, ezetimibe, lipoproteins, PCSK9 inhibitors, statin.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Packard, Professor Chris
• Authors: Packard, C. J.
• College/School: College of Medical Veterinary and Life Sciences; College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Current Cardiology Reports
• Publisher: Springer
• ISSN: 1523-3782
• ISSN (Online): 1534-3170
• Published Online: 14 June 2018
• Copyright Holders: Copyright © 2018 Springer Science+Business Media, LLC, part of Springer Nature
• First Published: First published in Current Cardiology Reports 20(8): 60
• Publisher Policy: Reproduced in accordance with the publisher copyright policy