Immune mechanisms in atherosclerosis and potential for immunomodulatory therapies

Grassia, G., MacRitchie, N. and Maffia, P. (2018) Immune mechanisms in atherosclerosis and potential for immunomodulatory therapies. In: Riccardi, C., Levi-Schaffer, F. and Tiligada, E. (eds.) Immunopharmacology and Inflammation. Springer: Cham, pp. 211-224. ISBN 9783319776576 (doi: 10.1007/978-3-319-77658-3_9)

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A considerable body of pre-clinical and clinical research data support a pivotal role played by immune-inflammatory responses in atherosclerosis formation and development. Recent clinical trial results confirm the feasibility of targeting immune pathways for the therapeutic control of the pathology. In this chapter, we discuss the key immune-inflammatory mechanisms involved in atherosclerosis development and progression and plaque destabilization. We discuss the anti-inflammatory pleiotropic effects of lipid-lowering drugs and potential therapeutic strategies for the direct control of vascular inflammation. Finally, we discuss vaccination approaches in atherosclerosis and critical questions that should be addressed in future investigations.

Item Type:Book Sections
Additional Information:Also funded by the European Commission Marie Skłodowska-Curie Individual Fellowships 661 and 369.
Glasgow Author(s) Enlighten ID:MacRitchie, Dr Neil and Maffia, Professor Pasquale and Grassia, Dr Gianluca
Authors: Grassia, G., MacRitchie, N., and Maffia, P.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Published Online:10 June 2018

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
614711Defining innate and adaptive immune functions of plasmacytoid dendritic cells in atherosclerosis.Pasquale MaffiaBritish Heart Foundation (BHF)PG/12/81/29897III -IMMUNOLOGY
617771BHF centre of excellenceRhian TouyzBritish Heart Foundation (BHF)RE/13/5/30177RI CARDIOVASCULAR & MEDICAL SCIENCES
644661In Situ Nanoparticle Assemblies for Healthcare Diagnostics and TherapyPasquale MaffiaEngineering and Physical Sciences Research Council (EPSRC)EP/L014165/1III -IMMUNOLOGY
718631Selective targeting of NF-??B by Bcl-3 in the control of vascular injuryGianluca GrassiaTenovus Scotland (TENOVUS)S15/24III -IMMUNOLOGY