Lua, J., Qayyum, T., Edwards, J. and Roseweir, A. K. (2018) The prognostic role of the non-canonical nuclear factor-kappa B pathway in renal cell carcinoma patients. Urologia Internationalis, 101(2), pp. 190-196. (doi: 10.1159/000489816) (PMID:30089311)
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Abstract
Background: In the United Kingdom, 8,000 cases of renal cancer are diagnosed each year, with a 5-year survival rate of 50%. Treatment options are limited; a potential therapeutic target is the non-canonical nuclear factor-kappa B (NF-κB) pathway. This pathway plays a role in multiple oncogenic processes in solid tumors. The aim of this study was to investigate the non-canonical nuclear factor pathway in renal cell carcinoma (RCC). Materials and Methods: NIK, IKKα, and RelB were investigated via immunohistochemistry in a cohort of 192 patients with clear cell renal cancer. Results: High cytoplasmic NIK was associated with poorer cancer-specific survival (p = 0.006) and 10-year survival stratified from 85% (low) to 65% (high, p = 0.005). Similarly, high cytoplasmic RelB was associated with poorer cancer-specific survival (p = 0.041) and 10-year survival stratified from 88% (low) to 73% (high, p = 0.030). When clinicopathological characteristics were assessed, cytoplasmic NIK was associated with survival (p = 0.014), whereas cytoplasmic RelB was associated with increased tumor grade (p = 0.020) and decreased inflammation (p = 0.019). Upon multivariate analysis, it was found that cytoplasmic NIK was independently associated with cancerspecific survival (p = 0.009). Conclusions: The non-canonical NF-κB pathway is associated with poorer cancer-specific survival in RCC patients, making it a viable target for therapeutic intervention. Furthermore, cytoplasmic NIK is a potential prognostic biomarker for this disease.
| Item Type: | Articles |
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| Additional Information: | This work was financially supported by Renal Cancer Scotland and the Wolfson Foundation. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Roseweir, Dr Antonia and Qayyum, Dr Tahir and Edwards, Professor Joanne |
| Authors: | Lua, J., Qayyum, T., Edwards, J., and Roseweir, A. K. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Urologia Internationalis |
| Publisher: | Karger |
| ISSN: | 0042-1138 |
| ISSN (Online): | 1423-0399 |
| Published Online: | 08 August 2018 |
| Copyright Holders: | Copyright © 2018 S. Karger AG |
| First Published: | First published in Urologia Internationalis 101(2): 190-196 |
| Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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