Gerasimidis, K. , Zafeiropoulou, K., Mackinder-Jonas, M., Ijaz, U. Z. , Duncan, H., Buchanan, E., Cardigan, T., Edwards, C. A. , McGrogan, P. and Russell, R. K. (2018) Comparison of clinical methods with the faecal gluten immunogenic peptide to assess gluten intake in coeliac disease. Journal of Pediatric Gastroenterology and Nutrition, 67(3), pp. 356-360. (doi: 10.1097/MPG.0000000000002062) (PMID:29916953)
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Abstract
Objectives: Detection of faecal gluten immunogenic peptides (GIP) is a biomarker of recent gluten consumption. GIP levels can be used to monitor gluten intake and compliment clinical methods to evaluate compliance to gluten free diet (GFD). In this study, recent gluten intake was measured by GIP in CD children and compared to routine clinical measures to evaluate GFD compliance. Methods: GIP was measured in 90 samples from 63 CD children (44 previously and 19 newly diagnosed with follow-up samples at 6 and 12 months on GFD). Compliance to GFD was evaluated based on clinical assessment, tTG levels and Biagi score. Results: GIP was detectable in 16% of patients with previous CD diagnosis on GFD. BMI z-score (p=0.774), height z-score (p=0.723), haemoglobin concentration (p=0.233), age (p=0.448), gender (p=0.734) or disease duration (p=0.488) did not differ between those with detectable and non-detectable GIP. In newly diagnosed patients, on gluten containing diet, GIP was detectable in 95% of them. Following GFD initiation, GIP decreased (p<0.001); 17% and 27% had detectable levels at 6 and 12 months, respectively. Compared to GIP, the Biagi score, tTG and clinical assessment presented sensitivity of 17%, 42% and 17%. Likewise, GIP was detectable in 16%, 16%, 14% of patients evaluated as GFD compliant according to the Biagi score, tTG and clinical assessment. A combination of methods did not improve identification of patients who were non-compliant. Conclusions: Inclusion of faecal GIP measurements is likely to improve identification of GFD recent noncompliance in CD management and could be incorporated into current follow-up strategies.
| Item Type: | Articles |
|---|---|
| Additional Information: | This study was funded by the University of Glasgow and the Nutricia Research Foundation, a European charity, through a competitive grant scheme. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Mackinder-Jonas, Mary and Gerasimidis, Professor Konstantinos and Edwards, Professor Christine and Ijaz, Dr Umer and Zafeiropoulou, Konstantina |
| Authors: | Gerasimidis, K., Zafeiropoulou, K., Mackinder-Jonas, M., Ijaz, U. Z., Duncan, H., Buchanan, E., Cardigan, T., Edwards, C. A., McGrogan, P., and Russell, R. K. |
| College/School: | College of Medical Veterinary and Life Sciences College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing College of Science and Engineering > Scottish Universities Environmental Research Centre |
| Journal Name: | Journal of Pediatric Gastroenterology and Nutrition |
| Publisher: | Lippincott, Williams and Wilkins |
| ISSN: | 0277-2116 |
| ISSN (Online): | 1536-4801 |
| Published Online: | 18 June 2018 |
| Copyright Holders: | Copyright © 2018 The Authors |
| First Published: | First published in Journal of Pediatric Gastroenterology and Nutrition 67(3): 356-360 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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