Burton, J. K. , Papworth, R., Haig, C. , McCowan, C. , Ford, I. , Stott, D. J. and Quinn, T. J. (2018) Statin use is not associated with future long-term care admission - extended follow-up of two randomised controlled trials. Drugs and Aging, 35(7), pp. 657-663. (doi: 10.1007/s40266-018-0560-4) (PMID:29916140)
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Abstract
Background: Statins have been associated with later life, long-term care admission in observational studies. However, by preventing vascular events, statins may also prevent or delay admission. We wished to determine statin and long-term care admission associations in a randomised controlled trial context, and describe associations between long-term care admission and other clinical and demographic factors. Methods: We used extended follow-up of two randomised trial populations, using national data to assign the long-term care admission outcome, and included individuals screened or recruited to two large randomised trials of pravastatin 40 mg daily—the West of Scotland Coronary Prevention Study (WOSCOPS) and the pravastatin in elderly individuals at risk of vascular disease (PROSPER) study. We described univariable and multivariable analyses of potential predictors of long-term care admission with corresponding survival curves of incident long-term care admission and analyses adjusted for competing risk. Results: In total 11,015 (10%) of the trial participants were admitted to long-term care. There was no difference between participants in the statin or placebo arms of either trial in regard to admissions to long-term care. On multivariable analyses, independent associations with incident long-term care admission in the PROSPER trial were age (hazard ratio [HR] 1.06 per year, 95% confidence interval [CI] 1.03–1.09) and male sex (HR 0.72, 95% CI 0.53–0.99). In the WOSCOPS, age (HR 1.12 per year, 95% CI 1.10–1.13) and increasing social deprivation (HR 1.05, 95% CI 1.03–1.08) were associated with incident long-term care admission. Conclusion: We did not demonstrate an association between historical statin use and future long-term care admission. The strongest associations with incident long-term care admission were non-modifiable factors of age, sex and socioeconomic deprivation.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Quinn, Professor Terry and Mccowan, Professor Colin and Stott J, Professor David and Haig, Dr Caroline and Burton, Dr Jenni and Ford, Professor Ian and Papworth, Dr Richard |
| Authors: | Burton, J. K., Papworth, R., Haig, C., McCowan, C., Ford, I., Stott, D. J., and Quinn, T. J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre |
| Journal Name: | Drugs and Aging |
| Publisher: | Adis |
| ISSN: | 1170-229X |
| ISSN (Online): | 1179-1969 |
| Published Online: | 19 June 2018 |
| Copyright Holders: | Copyright © 2018 Springer International Publishing AG, part of Springer Nature |
| First Published: | First published in Drugs and Aging 35(7): 657-663 |
| Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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