Schmitz, L., Gupta, G., Segert, M. H., Kost, R., Sternberg, J., Gambichler, T., Stockfleth, E. and Dirschka, T. (2018) Diclofenac sodium 3% in hyaluronic acid 2.5% gel significantly diminishes the actinic keratosis area and severity index. Skin Pharmacology and Physiology, 31(4), pp. 206-211. (doi: 10.1159/000488248) (PMID:29791916)
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Abstract
Background/Aims: Actinic keratosis area and severity index (AKASI) is a new assessment tool to quantify the severity of actinic damage on the head. Thus far, it has not been evaluated in monitoring the efficacy of field-directed topical treatments in actinic keratosis (AK) in routine clinical practice. Thus, the aim of this study was to determine treatment outcomes by using AKASI 3 months after the initiation of topical application of diclofenac sodium 3% in hyaluronic acid 2.5% gel (DFS) in patients with AKs on the head. Methods: We performed a retrospective analysis of patients with AKs who had AKASI scores prior to and after treatment with DFS. Results: Of the 24 patients included, 20 (83.3%) showed an improvement in AKASI, 2 (8.3%) a stable AKASI, and 2 (8.3%) a worsening of AKASI after a median (interquartile range) follow-up period of 91.5 days (89.8–104.3). The median AKASI reduction was 31.4% (16.7–59.1). The Wilcoxon test showed significant differences (p = 0.0008) between baseline and posttreatment AKASI values. Conclusions: AKASI is an easy-touse quantitative tool for assessing the treatment outcome of field-directed therapies. Field-directed therapies of AK should no longer be monitored by assessments based on lesion counts alone.
| Item Type: | Articles |
|---|---|
| Keywords: | AKASI, actinic keratosis, diclofenac sodium 3% gel, modified AKASI, NMSC. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Gupta, Dr Girish |
| Authors: | Schmitz, L., Gupta, G., Segert, M. H., Kost, R., Sternberg, J., Gambichler, T., Stockfleth, E., and Dirschka, T. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Skin Pharmacology and Physiology |
| Publisher: | Karger |
| ISSN: | 1660-5527 |
| ISSN (Online): | 1660-5535 |
| Published Online: | 23 May 2018 |
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