Tenecteplase for the treatment of acute ischemic stroke: a review of completed and ongoing randomized controlled trials

Coutts, S.B., Berge, E., Campbell, B.C.V., Muir, K.W. and Parsons, M.W. (2018) Tenecteplase for the treatment of acute ischemic stroke: a review of completed and ongoing randomized controlled trials. International Journal of Stroke, 13(9), pp. 885-892. (doi:10.1177/1747493018790024) (PMID:30035698)

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Abstract

Alteplase has been the mainstay of thrombolytic treatment since the National Institutes of Neurological Disorders and Stroke trial was published in 1995. Over recent years, several trials have investigated alternative thrombolytic agents. Tenecteplase, a genetically engineered mutant tissue plasminogen activator, has a longer half-life, allowing single intravenous bolus administration without infusion, is more fibrin specific, produces less systemic depletion of circulating fibrinogen, and is more resistant to plasminogen activator inhibitor compared to alteplase. Tenecteplase is established as the first-line intravenous thrombolytic drug for myocardial infarction, where it has been shown to achieve comparable reperfusion with reduced risk of systemic bleeding in comparison to alteplase. We review the literature on tenecteplase for the treatment of acute ischemic stroke, with a focus on the major completed and ongoing trials. Overall, tenecteplase shows promise for treatment of acute ischemic stroke, both in populations currently eligible for alteplase and also in groups not currently treated with thrombolysis.

Item Type:Articles (Editorial)
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Muir, Professor Keith
Authors: Coutts, S.B., Berge, E., Campbell, B.C.V., Muir, K.W., and Parsons, M.W.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:International Journal of Stroke
Publisher:SAGE Publications
ISSN:1747-4930
ISSN (Online):1747-4949
Published Online:23 July 2018
Copyright Holders:Copyright © 2018 World Stroke Organization
First Published:First published in International Journal of Stroke 13(9): 885-892
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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