Tsimvrakidis, K., Gemmell, N. R., Erotokritou, K., Miki, S., Yabuno, M., Yamashita, T., Terai, H. and Hadfield, R. H. (2019) Enhanced optics for time-resolved singlet oxygen luminescence detection. IEEE Journal of Selected Topics in Quantum Electronics, 25(1), 7000107. (doi: 10.1109/JSTQE.2018.2836962)
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162344.pdf - Published Version Available under License Creative Commons Attribution. 1MB |
Abstract
Singlet oxygen luminescence dosimetry (SOLD) is a highly promising direct monitoring method for photodynamic therapy (PDT) in the treatment of cancer. Early SOLD systems have been hampered by inefficient excitation, poor optical collection and immature infrared single photon detection technology. We report carefully engineered improvements addressing all of these deficiencies. We use a supercontinuum source with a tunable filter to precisely target the peak absorption wavelength of the chosen photosensitizer; we have designed a compact and versatile optical package for precise alignment; we have successfully employed state-of-the-art superconducting photon counting technologies. Through these improvements, we can achieve real-time histogram acquisition from a photosensitizer in solution test sample. This setup opens the pathway to physiological SOLD studies for PDT dosimetry.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Tsimvrakidis, Konstantinos and Hadfield, Professor Robert and Erotokritou, Mr Kleanthis |
| Authors: | Tsimvrakidis, K., Gemmell, N. R., Erotokritou, K., Miki, S., Yabuno, M., Yamashita, T., Terai, H., and Hadfield, R. H. |
| College/School: | College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering |
| Journal Name: | IEEE Journal of Selected Topics in Quantum Electronics |
| Publisher: | Institute of Electrical and Electronics Engineers |
| ISSN: | 1077-260X |
| ISSN (Online): | 1558-4542 |
| Published Online: | 22 May 2018 |
| Copyright Holders: | Copyright © 2018 IEEE |
| First Published: | First published in IEEE Journal of Selected Topics in Quantum Electronics 25(1): 7000107 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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