Genetic structure and dynamics of Plasmodium falciparum infections in the Kilombero region of Tanzania

Babiker, H. A., Ranford-Cartwright, L. C. and Walliker, D. (1999) Genetic structure and dynamics of Plasmodium falciparum infections in the Kilombero region of Tanzania. Transactions of the Royal Society of Tropical Medicine and Hygiene, 93(S1), pp. 11-14. (doi:10.1016/S0035-9203(99)90321-8) (PMID:10450420)

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Abstract

Plasmodium falciparum parasites exist as genetically distinct haploid clones in infected people. In the Kilombero valley in south-east Tanzania, at least 85% of the inhabitants of Michenga village harbour more than one clone. Using 2 highly polymorphic unlinked markers, it has been estimated that each infected person harbours between one and 6 P. falciparum clones at any one time, with a mean of 3·5 clones. When mosquitoes acquire gametocytes of 2 different clones in a blood meal, crossing generates recombinant clones differing from their parental genotypes. The inbreeding coefficient of the parasite population has been estimated as 0·33.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ranford-Cartwright, Dr Lisa
Authors: Babiker, H. A., Ranford-Cartwright, L. C., and Walliker, D.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:Transactions of the Royal Society of Tropical Medicine and Hygiene
Publisher:Elsevier
ISSN:0035-9203
ISSN (Online):1878-3503

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