Creasey, A. M., Ranford-Cartwright, L. C. , Moore, D. J., Williamson, D. H., Wilson, R. J.M., Walliker, D. and Carter, R. (1993) Uniparental inheritance of the mitochondrial gene cytochrome b in Plasmodium falciparum. Current Genetics, 23(4), pp. 360-364. (doi: 10.1007/bf00310900) (PMID:8467535)
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Abstract
The inheritance of an extrachromosomal 6-kb element has been examined in the human malaria parasite Plasmodium falciparum. A single base pair difference in the cytochrome b gene from the 6-kb element of two different cloned lines of the parasite was identified, and used as a marker in a cross in the mosquito stage of the life cycle. Analysis of 59 individual hybrid oocysts resulting from this cross clearly demonstrated that inheritance of the cytochrome b gene was uniparental. This observation makes it possible to investigate the inheritance and evolution of cytoplasmic traits, including certain forms of drug resistance, in natural populations of this parasite.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Ranford-Cartwright, Dr Lisa |
| Authors: | Creasey, A. M., Ranford-Cartwright, L. C., Moore, D. J., Williamson, D. H., Wilson, R. J.M., Walliker, D., and Carter, R. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Journal Name: | Current Genetics |
| Publisher: | Springer |
| ISSN: | 0172-8083 |
| ISSN (Online): | 1432-0983 |
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