Sheahan, A. V., Biankin, A. V. , Parish, C. R. and Khachigian, L. M. (2018) Targeted therapies in the management of locally advanced and metastatic pancreatic cancer: a systematic review. Oncotarget, 9(30), pp. 21613-21627. (doi: 10.18632/oncotarget.25085) (PMID:29765563) (PMCID:PMC5940404)
|
Text
162135.pdf - Published Version Available under License Creative Commons Attribution. 1MB |
Abstract
Pancreatic cancer has a dismal prognosis particularly in patients presenting with unresectable tumors. We performed a bibliometric analysis of clinical trials for pancreatic cancer conducted between 2014-2016 focusing on patients that presented with unresectable (locally advanced or metastatic) tumors. We discuss a range of studies that employed FOLFIRINOX, the gemcitabine + nab-paclitaxel combination and studies that used molecularly-targeted therapy. Major areas of focus have been dual targeting of EGFR and VEGFR, immunotherapy or a multimodal approach – combining chemotherapy with radiotherapy. We also point out the need for molecular selection for low prevalence subtypes. Key insights sourced from these pivotal trials should improve clinical outcomes for this devastating cancer.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Biankin, Professor Andrew |
| Authors: | Sheahan, A. V., Biankin, A. V., Parish, C. R., and Khachigian, L. M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Oncotarget |
| Publisher: | Impact Journals |
| ISSN: | 1949-2553 |
| ISSN (Online): | 1949-2553 |
| Copyright Holders: | Copyright © 2018 Sheahan et al. |
| First Published: | First published in Oncotarget 9(30):21613-21627 |
| Publisher Policy: | Reproduced under a Creative Commons License |
University Staff: Request a correction | Enlighten Editors: Update this record
Deposit and Record Details
Deposit and Record Details