Potential benefits of combining transfluthrin-treated sisal products and long-lasting insecticidal nets for controlling indoor-biting malaria vectors

Masalu, J. P., Okumu, F. O. , Mmbando, A. S., Sikulu-Lord, M. T. and Ogoma, S. B. (2018) Potential benefits of combining transfluthrin-treated sisal products and long-lasting insecticidal nets for controlling indoor-biting malaria vectors. Parasites and Vectors, 11(1), 231. (doi: 10.1186/s13071-018-2811-y) (PMID:29631633) (PMCID:PMC5891933)

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Abstract

Background: Transfluthrin vapour prevents mosquito bites by disrupting their host-seeking behaviors. We measured the additional benefits of combining transfluthrin-treated sisal decorations and long-lasting insecticidal nets (LLINs) with an aim of extending protection against early evening, indoor-biting malaria vectors when LLINs are ineffective. Methods: We investigated the indoor protective efficacy of locally made sisal decorative baskets (0.28 m2) treated with 2.5 ml and 5.0 ml transfluthrin, in terms of mosquito density, exposure to bites and 24 h mortality. Experiments were conducted in experimental huts, located in Lupiro village, Ulanga District, south-eastern Tanzania. Human landing catches (HLC) were used to measure exposure to bites between 19:00–23:00 h. Each morning, at 06:00 h, mosquitoes were collected inside huts and in exit traps and monitored for 24 h mortality. Results: Sisal decorative baskets (0.28 m2) treated with 2.5 ml and 5.0 ml transfluthrin deterred three-quarters of Anopheles arabiensis mosquitoes from entering huts (relative rate, RR = 0.26, 95% confidence interval, CI: 0.20–0.34, P < 0.001 and RR= 0.29, 95% CI: 0.22–0.37, P < 0.001, respectively). Both treatments induced a 10-fold increase in 24 h mortality of An. arabiensis mosquitoes (odds ratio, OR = 12.26, 95% CI: 7.70–19.51, P < 0.001 and OR = 18.42, 95% CI: 11.36–29.90, P < 0.001, respectively). Conclusions: Sisal decorative items treated with spatial repellents provide additional household and personal protection against indoor biting malaria and nuisance mosquitoes in the early evening, when conventional indoor vector control tools, such as LLINs, are not in use. We recommend future studies to investigate the epidemiological relevance of combining LLINs and transfluthrin decorated baskets in terms of their effect on reduction in malaria prevalence.

Item Type:Articles
Additional Information:The study was funded by Grand Challenges Canada (Grant number: S5 0440-01). FOO was also supported by Wellcome Trust Intermediate Fellowship in Public Health and Tropical Medicine (Grant number: WT102350/Z/13/Z). ASM is also supported by Wellcome Trust Masters Fellowship (Grant number: WT106356/Z/14/Z).
Keywords:Early-evening biting, LLINs, residual malaria transmission, spatial repellents, transfluthrin.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Okumu, Professor Fredros
Authors: Masalu, J. P., Okumu, F. O., Mmbando, A. S., Sikulu-Lord, M. T., and Ogoma, S. B.
College/School:College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
Journal Name:Parasites and Vectors
Publisher:BioMed Central
ISSN:1756-3305
ISSN (Online):1756-3305
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Parasites and Vectors 11(1):231
Publisher Policy:Reproduced under a Creative Commons License

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