Droescher, M., Chaugule, V. K. and Pichler, A. (2013) SUMO rules: regulatory concepts and their implication in neurologic functions. NeuroMolecular Medicine, 15(4), pp. 639-660. (doi: 10.1007/s12017-013-8258-6) (PMID:23990202)
Full text not currently available from Enlighten.
Abstract
Posttranslational modification of proteins by the small ubiquitin-like modifier (SUMO) is a potent regulator of various cellular events. Hundreds of substrates have been identified, many of them involved in vital processes like transcriptional regulation, signal transduction, protein degradation, cell cycle regulation, DNA repair, chromatin organization, and nuclear transport. In recent years, protein sumoylation increasingly attracted attention, as it could be linked to heart failure, cancer, and neurodegeneration. However, underlying mechanisms involving how modification by SUMO contributes to disease development are still scarce thus necessitating further research. This review aims to critically discuss currently available concepts of the SUMO pathway, thereby highlighting regulation in the healthy versus diseased organism, focusing on neurologic aspects. Better understanding of differential regulation in health and disease may finally allow to uncover pathogenic mechanisms and contribute to the development of disease-specific therapies.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Chaugule, Dr Viduth |
| Authors: | Droescher, M., Chaugule, V. K., and Pichler, A. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
| Journal Name: | NeuroMolecular Medicine |
| Publisher: | Humana Press |
| ISSN: | 1535-1084 |
| ISSN (Online): | 1559-1174 |
| Published Online: | 30 August 2013 |
University Staff: Request a correction | Enlighten Editors: Update this record
Altmetric
Altmetric