Gender differences in stability of the instantaneous patterns of body surface potentials during ventricular repolarisation

Corlan, A.D., Macfarlane, P.W. and De Ambroggi, L. (2003) Gender differences in stability of the instantaneous patterns of body surface potentials during ventricular repolarisation. Medical and Biological Engineering and Computing, 41(5), pp. 536-542. (doi:10.1007/BF02345315)

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Abstract

Women have a higher risk of developing torsade de pointes under QT-prolonging conditions. The electrophysiological differences between the sexes that could account for this are largely unknown. The objective of the work was to evaluate gender differences in repolarisation potentials using a method that is independent of the specific electrical properties of the thorax. 1410 normal recordings from the Glasgow 12-lead ECG database and 52 normal ECG maps obtained separately in Milan were analysed. The average difference between 1 and the correlation coefficient of the instantaneous pattern at the peak of T with that at every other instant is called the early repolarisation deviation index (ERDI) for J-T peak and the late repolarisation deviation index (LRDI) for T peak-T end. In standard ECG recordings, the ERDI was 0.42±0.22 in females compared with 0.19±0.16 in males (p<10−6). The LRDI was higher in males under the age of 50. In body surface maps, the ERDI was 0.32±0.21 in females against 0.16±0.17 in males (p<0.01), and the LRDI was non-significantly higher in males. The pattern of instantaneous body surface potentials showed gender differences during repolarisation with a method that is independent of the electrical properties of the thorax.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Macfarlane, Professor Peter
Authors: Corlan, A.D., Macfarlane, P.W., and De Ambroggi, L.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Medical and Biological Engineering and Computing
ISSN:0140-0118

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