Corlan, A.D., Macfarlane, P.W. and De Ambroggi, L. (2003) Gender differences in stability of the instantaneous patterns of body surface potentials during ventricular repolarisation. Medical and Biological Engineering and Computing, 41(5), pp. 536-542. (doi: 10.1007/BF02345315)
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Abstract
Women have a higher risk of developing torsade de pointes under QT-prolonging conditions. The electrophysiological differences between the sexes that could account for this are largely unknown. The objective of the work was to evaluate gender differences in repolarisation potentials using a method that is independent of the specific electrical properties of the thorax. 1410 normal recordings from the Glasgow 12-lead ECG database and 52 normal ECG maps obtained separately in Milan were analysed. The average difference between 1 and the correlation coefficient of the instantaneous pattern at the peak of T with that at every other instant is called the early repolarisation deviation index (ERDI) for J-T peak and the late repolarisation deviation index (LRDI) for T peak-T end. In standard ECG recordings, the ERDI was 0.42±0.22 in females compared with 0.19±0.16 in males (p<10−6). The LRDI was higher in males under the age of 50. In body surface maps, the ERDI was 0.32±0.21 in females against 0.16±0.17 in males (p<0.01), and the LRDI was non-significantly higher in males. The pattern of instantaneous body surface potentials showed gender differences during repolarisation with a method that is independent of the electrical properties of the thorax.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Macfarlane, Professor Peter |
Authors: | Corlan, A.D., Macfarlane, P.W., and De Ambroggi, L. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
Journal Name: | Medical and Biological Engineering and Computing |
ISSN: | 0140-0118 |
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