Regulation of the cardiac Na+ pump by palmitoylation of its catalytic and regulatory subunits

Howie, J., Tulloch, L. B., Shattock, M. J. and Fuller, W. (2013) Regulation of the cardiac Na+ pump by palmitoylation of its catalytic and regulatory subunits. Biochemical Society Transactions, 41(1), pp. 95-100. (doi: 10.1042/BST20120269) (PMID:23356265)

Abstract

The Na+/K+-ATPase (Na+ pump) is the principal consumer of ATP in multicellular organisms. In the heart, the Na+ gradient established by the pump is essential for all aspects of cardiac function, and appropriate regulation of the cardiac Na+ pump is therefore crucial to match cardiac output to the physiological requirements of an organism. The cardiac pump is a multi-subunit enzyme, consisting of a catalytic α-subunit and regulatory β- and FXYD subunits. All three subunits may become palmitoylated, although the functional outcome of these palmitoylation events is incompletely characterized to date. Interestingly, both β- and FXYD subunits may be palmitoylated or glutathionylated at the same cysteine residues. These competing chemically distinct post-translational modifications may mediate functionally different effects on the cardiac pump. In the present article, we review the cellular events that control the balance between these modifications, and discuss the likely functional effects of pump subunit palmitoylation.

• Item Type: Articles
• Additional Information: This work was supported by a grant from the British Heart Foundation to W.F. and M.J.S. [grant number RG/07/001].
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Howie, Dr Jacqueline and Fuller, Professor Will
• Authors: Howie, J., Tulloch, L. B., Shattock, M. J., and Fuller, W.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Biochemical Society Transactions
• Publisher: Portland Press
• ISSN: 0300-5127
• ISSN (Online): 1470-8752
• Published Online: 29 January 2013