Gastrointestinal stromal tumour as a rare association with neurofibromatosis type 1

Hurley, R. H., McCormick, M., Elhassan, M. and Nicholson, G. (2018) Gastrointestinal stromal tumour as a rare association with neurofibromatosis type 1. Journal of Surgical Case Reports, 2018(2), rjy017. (doi: 10.1093/jscr/rjy017) (PMID:29492250) (PMCID:PMC5822698)

Abstract

Gastrointestinal stromal tumours (GIST) are rare tumours of mesenchymal origin. These can be associated with neurofibromatosis type 1 (NF1), which is an autosomal dominant disorder. The prevalence of GIST in NF1 is estimated at 3.9-25%. This paper describes the presentation of a GIST arising from the jejenum in a 75-year-old lady with NF1, who presented with gastrointestinal bleeding. This was diagnosed by CT angiography. She was managed with laparotomy, with resection of small bowel, and an ischaemic segment of large bowel with two primary anastomoses. Pathology showed GIST of spindle cell type (Figs 3 and 4), 90 mm in size, with complete local excision. The patient was discharged on the eighth post-operative day and is currently undergoing regular clinic follow-up after multidisciplinary team meeting discussion.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Nicholson, Mr Gary
• Authors: Hurley, R. H., McCormick, M., Elhassan, M., and Nicholson, G.
• College/School: College of Medical Veterinary and Life Sciences > School of Life Sciences; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Journal of Surgical Case Reports
• Publisher: Oxford University Press
• ISSN: 2042-8812
• ISSN (Online): 2042-8812
• Published Online: 21 February 2018
• Copyright Holders: Copyright © 2018 The Authors
• First Published: First published in Journal of Surgical Case Reports 2018(2): rjy017
• Publisher Policy: Reproduced under a Creative Commons License