Impact of cell density and collagen concentration on the electromagnetic properties of dermal equivalents in the terahertz band

Zhang, R., Yang, K., Abbasi, Q. H. , AbuAli, N. A. and Alomainy, A. (2018) Impact of cell density and collagen concentration on the electromagnetic properties of dermal equivalents in the terahertz band. IEEE Transactions on Terahertz Science and Technology, 8(4), pp. 381-389. (doi: 10.1109/TTHZ.2018.2825111)

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Abstract

In this paper, the measurement of collagen gels and dermal equivalents (DEs) with three kinds of fibroblast cell densities and collagen concentrations is performed, respectively, using terahertz time-domain spectroscopy (THz-TDS) in transmission mode. With the objective to reduce the thickness uncertainty, an algorithm to extract material parameters and sample thickness of thin samples simultaneously is employed. The statistical mean and standard deviation of the refractive indexes and absorption coefficients in a THz band from 0.2 to 1.5 THz are presented. It is shown that the refractive indexes of DEs drop by around 10%, whereas the absorption coefficients decrease by 20% when cell density increases by one order from 0.1 to 1 M/mL. In addition, the complex refractive indexes of DEs with 3-mg/mL collagen are higher than those with 2 mg/mL, whereas the THz optical parameters of DEs with 2.5 mg/mL are the lowest. The obtained results indicate that the difference in the intrinsic biological features, initial cell density, and collagen concentration changes the tissue hydration, which in turn brings changes to the electromagnetic properties.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Abbasi, Professor Qammer and Yang, Dr Ke
Authors: Zhang, R., Yang, K., Abbasi, Q. H., AbuAli, N. A., and Alomainy, A.
College/School:College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering
Journal Name:IEEE Transactions on Terahertz Science and Technology
Publisher:IEEE
ISSN:2156-342X
ISSN (Online):2156-3446
Published Online:02 May 2018
Copyright Holders:Copyright © 2018 IEEE
First Published:First published in IEEE Transactions on Terahertz Science and Technology 8(4): 381-389
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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