Apoptosis and cancer: force awakens, phantom menace, or both?

Cao, K. and Tait, S. W.G. (2018) Apoptosis and cancer: force awakens, phantom menace, or both? In: Galluzzi, L. (ed.) International Review of Cell and Molecular Biology. Elsevier, pp. 135-152. ISBN 9780128151952 (doi: 10.1016/bs.ircmb.2017.12.003)

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Apoptotic cell death serves as an important tumor suppressor mechanism at multiple steps during cancer progression. Equally, engagement of apoptosis represents a potent therapeutic effector mechanism. Nevertheless, the role of apoptosis in cancer may be more complex than previously thought. Indeed, various studies have found that apoptosis signaling also has oncogenic potential. In this review, we discuss how apoptosis can promote cancer and how these effects might be targeted to optimize apoptosis-inducing anticancer therapy.

Item Type:Book Sections
Keywords:Apoptosis, cancer, cell death, mitochondria, therapy.
Glasgow Author(s) Enlighten ID:Tait, Professor Stephen and Cao, Dr Kai
Authors: Cao, K., and Tait, S. W.G.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:International review of cell and molecular biology

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