O'Leary, L., Hughes-Mccormack, L., Dunn, K. and Cooper, S.-A. (2018) Early death and causes of death of people with Down syndrome: a systematic review. Journal of Applied Research in Intellectual Disabilities, 31(5), pp. 687-708. (doi: 10.1111/jar.12446) (PMID:29573301)
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Abstract
Background: It is thought that people with Down syndrome die younger than the general population, but that survival rates are improving. Methods: Five databases were searched for keywords related to intellectual disabilities, Down syndrome and mortality. Strict inclusion criteria were applied. Information from 34 selected studies was tabulated, extracted and synthesized. Results: People with Down syndrome died about 28 years younger than the general population. Congenital heart anomalies, comorbidities, low birthweight, and Black and minority ethnicity influenced earlier age of death, as did younger maternal age and poorer parental education. Congenital heart anomalies and respiratory conditions were the leading causes of death, and more common than in the general population. Survival rates have improved over time, particularly for those with congenital heart anomalies. Conclusions: People with Down syndrome are living longer but still die younger of different causes than the general population. More robust comparative data are needed, and ethnic differences require further study.
Item Type: | Articles |
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Additional Information: | Funding information: Scottish Government via the Scottish Learning Disabilities Observatory. |
Keywords: | Education, developmental and educational psychology. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Hughes, Mrs Laura and O'Leary, Dr Lisa and Dunn, Mrs Kirsty and Cooper, Professor Sally-Ann |
Authors: | O'Leary, L., Hughes-Mccormack, L., Dunn, K., and Cooper, S.-A. |
College/School: | College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Mental Health and Wellbeing |
Journal Name: | Journal of Applied Research in Intellectual Disabilities |
Publisher: | Wiley |
ISSN: | 1360-2322 |
ISSN (Online): | 1468-3148 |
Published Online: | 24 March 2018 |
Copyright Holders: | Copyright © 2018 John Wiley and Sons Ltd |
First Published: | First published in Journal of Applied Research in Intellectual Disabilities 31(5): 687-708 |
Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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