Relación entre modelado miocárdico y función diastólica en pacientes con hipertensión esencial = Relationship between myocardial modelling and diastolic function in patients with essential hypertension

Cortés, R. et al. (2012) Relación entre modelado miocárdico y función diastólica en pacientes con hipertensión esencial = Relationship between myocardial modelling and diastolic function in patients with essential hypertension. Medicina Clínica, 139(8), pp. 325-330. (doi: 10.1016/j.medcli.2011.08.008) (PMID:22036455)

Abstract

Background and objectives: To analyze the relationship between sFas and soluble TNF receptor 1 (sTNF-R1) with type iii (PIIINP) and i (PINP) amino-terminal propeptide procollagens, and diastole in hypertension (HT). Patients and methods: A group of 253 Caucasian asymptomatic hypertensive patients (age 60 ± 13 years, 139 males) were studied, in whom a physical examination, laboratory analyses (determination of serum PIIINP, PINP, sFas and by radioimmunoassay and ELISA, respectively), and echo-Doppler study were performed. Results: Serum PINP and PIIINP were increased in left ventricular hypertrophy compared to non-hypertrophy [41 (31-52) vs. 35 (28-47) μg/l, P = .010; and 4.33 (3.71-5.29) vs. 3.98 (3.49-4.58) μg/l, P = .005, respectively]. Furthermore, sFas and sTNF-R1 were also elevated [1.47 (1.2-1.77) vs. 1.37 (1.1-1.59), P = .012; and 466 (331-657) vs. 317 (260-427) μg/l, P < .0001, respectively]. Moreover, serum PIIINP was associated with sFas (r = .386, P < .0001) and sTNF-R1 (r = .298, P < .001); PINP was also associated with these cytokines (r = 0.158, P = .011 and r = .241, P < .0001, respectively). Multivariable analyses included sFas (P < .0001) and sTNF-R1 (P < .0001) as independent factors related with serum PIIINP. Finally, marker concentrations were significantly related with left ventricular diastolic function parameters. Conclusion: Procollagen and anti-apoptotic cytokine levels were increased in our hypertrophic patients. Furthermore, sFas and sTNF-R1 are independent related factors of serum PIIINP. Diastolic parameters were associated with myocardial fibrosis and anti-apoptotic cytokines.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Carpena Garcia, Miss Nuria
• Authors: Cortés, R., Roselló-Lletí, E., Portolés, M., Almenar, L., Martínez-Dolz, L., Grigorian, L., García de Burgos, F., Carpena, N., Salvador, A., Bertomeu, V., and Rivera, M.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: Medicina Clínica
• Publisher: Elsevier
• ISSN: 0025-7753
• ISSN (Online): 1578-8989